Within 15 to 20 years, 50 to 60 percent of relapsing-remitting MS patients would advance to secondary progressive form if not effectively treated ( Noseworthy et al., 2000). Although myelin regeneration may repair demyelinating nerve cell lesions in the early stages of MS, self-repair is no longer able to compensate for nerve cell damage and loss as the area of damage expands, resulting in the secondary progressive MS stage. In its early stages, MS has an alternating relapse-remitting clinical course, with relapses typically characterized by acute episodes of neurological impairments, depending on the location of the lesion and the severity of the inflammatory process ( Compston and Coles, 2008 Marisa et al., 2021). Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young and middle-aged individuals, resulting in a high incidence of neurological impairment and imposing an enormous personal and economic burden on patients, their families, and society ( Brownlee et al., 2017 Thompson et al., 2018b). The association between APTw, DTI parameters and clinical factors implies that they may play a role in disease damage monitoring. sNfL was considerably positively correlated with MTRasym (3.5 ppm) ( P = 0.043, R = 0.38) and disease durations were significantly negatively correlated with FA ( P = 0.046, R = −0.37).Ĭonclusion: Amide proton transfer-weighted (APTw) and DTI are potential imaging methods for assessing brain lesions in patients with MS at the molecular and microscopic levels, respectively. Results: The MTRasym (3.5 ppm) and ADC values of brain lesions were increased, while FA values were decreased in patients with MS. The associations between MTRasym (3.5 ppm), ADC, and FA values and the clinical measurements were investigated further. The diagnostic efficacy of MTRasym (3.5 ppm), ADC, and FA in the lesions of MS patients was compared using receiver operating characteristic (ROC) curve analysis. (2) The WM around each HC’s lateral ventricle (frontal lobe, parietal lobe, and centrum semiovale) was assessed bilaterally. The ROI criteria were: (1) for MS patients, ROI were defined as MS lesions, and each lesion was identified. MTRasym (3.5 ppm), ADC, FA values for MS and HC are calculated using mean values from all regions of interest (ROI). APTw and DTI images were registered to FLAIR-SPIR images and assessed by two neuroradiologists. APT-weighted (APTw) and diffusion tensor imaging (DTI) data were acquired using a 3.0-T magnetic resonance system.
Materials and methods: Twenty-nine patients with relapsing-remitting MS (21 females and 8 males) and 30 HCs (23 females and 7 males) were recruited. Objectives: To compare the signal alterations of amide proton transfer (APT), apparent diffusion coefficient (ADC), and fractional anisotropy (FA) in white matter (WM) lesions in multiple sclerosis (MS), compared with healthy controls (HCs), and to investigate the relationships between these changes and clinical measurements such as serum neurofilament light chain (sNfL).
3Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.2Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing, China.1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.Jing Huang 1,2, Yan Liang 3, Yi Shan 1,2, Cheng Zhao 1,2, Qiongge Li 1,2, Zhiwei Shen 4, Huiqing Dong 3, Zhigang Qi 1,2 and Jie Lu 1,2*
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